张洪波

E-mail: hbzhang@ecust.edu.cn
职位: 博士生导师
职称: 教授

个人简介:   

　　张洪波 教授 博士生导师 毕业于华中科技大学，2004年获得英国诺丁汉特伦特大学 博士学位。2004-2006分别在英国女王大学和伦敦大学作博士后研究。2006.10月就职于9159金沙游戏致力微流体技术在生物医药中的应用研究。先后受到国家自然科学基金、上海市对外合作基金、上海市飞利浦合作基金、上海市创新行动计划等项目资助，与英国女王大学、伦敦大学及国内近10家医疗机构开展了广泛的合作。中国生物材料协会先进制造分会委员；3D打印专业委员会委员；在3D生物打印技术及器官芯片技术方面发表50余篇SCI论文，十余项专利授权。

联系方法:

梅陇路130号9159金沙游戏401信箱，上海 200237

　　Tel: 0086-21-64253538

　　Email: hbzhang@ecust.edu.cn

研究方向

   (1）生物 3D 打印技术

　　生物 3D 打印构建骨、皮肤、气管组织及肿瘤模型；

　　开发熔融及电纺、挤出式及光固化生物3D打印技术

　(2）微流控与器官芯片技术 

　　微纳米颗粒、肿瘤细胞分离及载药缓释微球、微泡造影剂制备

　　模拟体内微环境，构建皮肤、肾器官芯片用于药物筛选；

　(3）个性化可穿戴智能型外骨骼护具及智能传感开发

　　构建柔性欠驱动假肢、肩、肘、手可穿戴式外骨骼护具；

　　姿态捕捉及生理信号结合用于步态、能耗分析及康复效果评估 

承担科研项目

　　承担项目：

　　（1）上海市科委创新行动计划 新型抗菌水凝胶敷料的研发和临床前评价，2019.4-2022.3

　　（2）上海市科委“联盟计划” 3D打印活体皮肤组织块用于药物筛选研发，2016.7-2018.1

　　（3）国家自然科学青年基金，微气泡造影剂对癌症的基因治疗的基础研究，2008-2010；

　　（4）上海市科委非政府合作基金，微流体聚焦法制备治疗型微气泡造影剂的研究，2010-2012；

　　（5）上海市飞利浦合作基金，治疗型微气泡造影剂新型制备方法的可行性研究，2007-2009；

　　企业合作项目：

          获得多项企业、医疗机构联合课题资助

获奖成果

        (1) 2014年获得9159金沙游戏育英奖一等奖；

        (2) 2013年获得上海市教学成果一等奖：机械与化工复合型人才多维度工程能力培养的研究与实践；

        (3) 2013年上海化工区理工教学二等奖

代表性著作

(1)  Jianxu Wei, Xiaomeng Zhang, Zhuo Zhang, Xinxin Ding, Yuan Li, Yi Zhang, Xue Jiang, Hongbo Zhang*, Hongchang Lai* 1, Junyu Shi* . On-off Switch of Bioenergetic Channels Regulated by Curcumin-loaded 3D Composite Scaffold to Steer Bone Regeneration. Chemical Engineering Journal, 2023, 452(1):139165.

(2) Pan Aixing, Ding Hongtao, Wang Junjie, Zhang Zhuo, Zhang Hongbo, Liu Yuzeng and Hai Yong. The application of finite element analysis to determine the optimal UIV of growing rod treatment in early-onset scoliosis. Front. Bioeng. Biotechnol. 2022,10:978554. doi: 10.3389/fbioe.2022.978554

(3)   Ruixue Yin, Jizhong Xin , Dasheng Yang , Yang Gao , Hongbo Zhang *, Zhiqin Qian and Wenjun Zhang ，High-Linearity Hydrogel-Based Capacitive Sensor Based on Con A–Sugar Affinity and Low-Melting-Point Metal，Polymers 2022, 14, 4302.

(4)   Wenxuan Sun, Zijia Liu , Jian Xu , Ya Cheng , Ruixue Yin , Lei Ma , Honglin Li , Xuhong Qian , Hongbo Zhang* , 3D skin models along with skin-on-a-chip systems: A critical review, Chinese Chemical Letters, 2022，107819. doi:https://doi.org/10.1016/j.cclet.2022.107819

(5)  Di Yin, Hongbo Zhang, Chun Yang, Wenjun Zhang, and Shihmo Yang. A More Biomimetic Cell Migration Assay with High Reliability and Its Applications, Pharmaceuticals 2022, 15(6), 695; https://doi.org/10.3390/ph15060695

(6)  Yilin Yan, Katharine Smith*, Alejandro Macario-Rojas and Hongbo Zhang *, Simulation of the Landing Buffer of a Three-Legged Jumping Robot. Machines 2022,10,299. https:// doi.org/10.3390/machines10050299

(7) ShihMoYang, QiangLin, HongboZhang,RuixueYin, Wenjun Zhang, Minchao Zhang,Yubao Cui. Dielectrophoresis assisted high-throughput detection system for multiplexed immunoassays. Biosensors and Bioelectronics, 180, 15 May 2021, 113148. https://doi.org/10.1016/j.bios.2021.113148

(8)  Yingjie Cai, Dasheng Yang, Ruixue Yin*, Yang Gao*, Hongbo Zhang* and Wenjun Zhang, An enzyme-free capacitive glucose sensor based on dual-network glucose-responsive hydrogel and coplanar electrode, The Analyst, 2021,146(1), 213-221.

(9) Zhitao Liu, Hongbo Zhang* and Huanxin Lai*, Fluid flow effects on the degradation kinetics of bioresorbable polymers, Computer Methods in Biomechanics and Biomedical Engineering, 2021, DOI: 10.1080/10255842.2020.1867115.

(10) Tiandi Wang, Jianchao Zheng, Tianzhou Hu, Hongbo Zhang, Kun Fu, Ruixue Yin and Wenjun Zhang. Three-Dimensional Printing of Calcium Carbonate/Hydroxyapatite Scaffolds at Low Temperature for Bone Tissue Engineering. 3D printing and additive manufacturing, 2021, 8(1)，1-13. DOI: 10.1089/3dp.2020.0140.

(11) Jinling Zhu,Minqi Wang, Hongbo Zhang*,Shengbing Yang*, Ki-Young Song, Ruixue Yin and Wenjun Zhang. Effects of Hydrophilicity, Adhesion Work, and Fluid Flow on Biofilm Formation of PDMS in Microfluidic Systems. ACS Applied Bio Materials, 2020, 3. 10.1021/acsabm.0c00660.

(12) P.W. Xu, F.L. Jiang, H.B. Zhang*, R.X. Yin, L. Cen and W.J. Zhang*.  Calcium Carbonate / Gelatin Methacrylate Microspheres for 3D Cell Culture in Bone Tissue Engineering Part C, 2020, 26 (8), 418-432. (IF:2.608)

(13)S.Y. Gai, J.J. Xu, H.B. Zhang*, R.X. Yin and W.J. Zhang*. Effects of Nanofillers on the Hydrolytic Degradation of Polyesters. Tissue engineering part B, March, 5th, 2020, published online. （IF:6.512)

(14) L. Lei, H.B. Zhang*, D. Bergstrom, T. Anthony, K.Y.Song, W.J. Zhang*. Experimental and simulation study of flow patterns in the combined flow focusing and T-junction device. Journal of Micromechanics and Microengineering, 2020, 30, 055001. (IF: 2.15)

(15) H.P. Si, T.L. Xing, Y.L. Ding, H.B. Zhang*, R.X. Yin and W.J. Zhang. 3D Bioprinting of the Sustained Drug Release Wound Dressing with Double-Crosslinked Hyaluronic-Acid-Based Hydrogels. Polymers 2019, 11(10), 1584.（IF:3.363）

(16) Y.H. Jia, H.B. Zhang*, S.B. Yang*, Z.H. Xi, T.T. Tang, R.X. Yin, W.J. Zhang. Electrospun PLGA membrane incorporated with Andrographolide-loaded Mesoporous Silica Nanoparticles for sustained antibacterial wound dressing. Nanomedicine, 2018, 13(22):2881-2899. (IF:5.005

(17) C.H. Ma, H.B. Zhang*, S. M. Yang, R. X. Yin, X. J. Yao, and W. J. Zhang. Comparison of the degradation behavior of PLGA scaffolds in micro-channel, shaking, and static conditions. Biomicrofluidics, 2018, 12, 034106.（IF:2.571）

(18)Y. Shi, T.L. Xing, H.B. Zhang*, R.X. Yin, Sh. M. Yang, J. Wei and W.J. Zhang. Tyrosinase doped bioink for 3D bioprinting of living skin constructs. Biomedical materials, 2018, 13, 035008.（IF:2.897）

(19) Y. Yang, L.Y. Chu, S.B. Yang, H.B. Zhang, L. Qin, O. Guillaume, D. Eglin, R. G. Richards, T.T. Tang. Dual-functional 3D-printed composite scaffold for inhibiting bacterial infection and promoting bone regeneration in infected bone defect models. Acta Biomaterialia, 2018, 79:265-275 46:112-128.（IF:6.319）

(20) S.B. Yang, X.G. Han, Y.H. Jia, H.B. Zhang* and T.T. Tang*. Hydroxypropyltrimethyl Ammonium Chloride Chitosan Functionalized-PLGA Electrospun Fibrous Membranes as Antibacterial Wound Dressing: In Vitro and In Vivo Evaluation. Polymers 2017, 9(12), 697.（IF:3.363）

(21) L. Lei, D. Bergstrom, B. Zhang, H.B. Zhang*, R. Yin, K.Y. Song and W.J. Zhang*. Micro/Nanospheres Generation by Fluid-Fluid Interaction Technology: A Literature Review. Recent Patents on Nanotechnology, 2017, 11, 15-33.（IF: 1.475）

(22) R. Yin, N. Zhang, K. Wang, H. Long, T.L. Xing, J. Nie, H.B. Zhang and W.J. Zhang. Material design and photo-regulated hydrolytic degradation behavior of tissue engineering scaffolds fabricated via 3D fiber deposition. Journal of Materials Chemistry B, 2017, 5, 329-340.（IF:4.543）

(23) Z.M. Du, N.F. Li, Y.J. Hua, Y. Shi, C.Y. Bao, H.B. Zhang, Y. Yang, Q.N. Lin, L.Y.  Zhu. Physiological pH-dependent gelation for 3D printing based on the phase separation of gelatin and oxidized dextran. Chemical Communication, 2017, 53(97):13023-13026. (IF:6.29) 

(24) H.B. Zhang*, T.L.Xing, Y. Shi, R.X.Yin, S.M.Yang and W.J. Zhang. 3D bioprinting is not only about cell-laden structures. Chinese Journal of Traumatology, 2016, 19:187-192. (MEDLINE)

(25) S. Duan, K. Yang, Z.H. Wang, M.T. Chen, L. Zhang*, H.B. Zhang* and C.Z. Li, Fabrication of Highly Stretchable Conductors Based on 3D Printed Porous Poly(dimethylsiloxane) and Conductive Carbon Nanotubes/Graphene Network, ACS Applied Materials & Interface, 2016, 27;8(3):2187-92.（IF:8.097）

(26) Y. Yang, S.B. Yang, Y. Wang, Z.F. Yu, H.Y. Ao, H.B. Zhang, L. Qin, O. Guillaume, D. Eglin, R.G. Richards and T.T. Tang. Anti-infective efficacy, cytocompatibility and biocompatibility of a 3D-printed osteoconductive composite scaffold functionalized with quaternized chitosan, Acta Biomaterialia, 2016, 46:112-128.（IF:6.319）

(27) H.B. Zhang, L. Zhou, and W.J. Zhang*. Control of Scaffold Degradation in Tissue Engineering: A Review. Tissue Engineering Part B, 2014, 10(5), 492-502.（IF:6.512）

(28) J. Xu, Y. Xie, H.B. Zhang*, Z. Ye*, W.J. Zhang. Fabrication of PLGA/MWNTs composite electrospun fibrous scaffolds for improved myogenic differentiation of C2C12 cells. Colloids and Surfaces B: Biointerfaces, 2014, 123, 907-915.（IF:3.977）

(29) B. Zhang, M.A.J. Moser, E.M. Zhang, Y. Luo, H.B. Zhang, W.J.  Zhang. Study of the relationship between the target tissue necrosis volume and the target tissue size in liver tumours using two-compartment finite element RFA modelling. International Journal of Hyperthermia, 2014; 30(8): 593-602. （IF:3.262）

(30)H.B. Zhang, Y.Y. Yan, Y.Q. Zu. Numerical modelling of EHD effects on heat transfer and bubble shapes of nucleate boiling. Applied Mathematical Modeling, 2010, 34: 626-638.（IF:2.68）

(31) J. Wei, J.F. Jia, F. Wu, S.C. Wei, H. Zhou, H.B. Zhang. Hierarchically microporous /macroporous scaffold of magnesium–calcium phosphate for bone tissue regeneration. Biomaterials, 2010, 31, 1260–1269. (IF:8.4604) 

(32) Z. Ahmad, H.B. Zhang, U. Farook, M. Edirisinghe, E. Stride, P. Colombo. Generation of multilayered structures for biomedical applications using a novel tri-needle coaxial device and electrohydrodynamic flow.Journal of the Royal Society Interface, 2008, 5(27), 1255-1261.（IF: 3.574）

(33) U. Farook, H.B. Zhang, M. Edirisinghe, E. Stride, N. Saffari. Preparation of microbubble suspensions by co-axial electrohydrodynamic atomization. Medical Engineering Physics. 2007, 29(7): 749-754. (IF:1.819）

(34) H.B. Zhang and M.J. Edirisinghe. Electrospinning of Zirconia fibers from a suspension, Journal of American Ceramic Society. 2006, 89 (6): p1870-1875.（IF:2.956）

(35) H.B. Zhang, S.N. Jayasinghe and M.J. Edirisinghe. Electrically forced microthreading of highly viscous dielectric liquids, Journal of Electrostatics, 2006, 64, p355-360.（IF:1.135）

(36) H.B. Zhang, M.J. Edirisinghe and S.N. Jayasinghe. Flow behaviour of dielectric liquids in an electric field, Journal of Fluid Mechanics, 2006, 558: p103-111.（IF:2.821）

(37) Q.Z. Chen, A.R. Boccaccini, H.B. Zhang, D.Z. Wang and M.J. Edirisinghe. Improved mechanical reliability of bone tissue engineering Scaffolds (zirconia) by electrospraying, Journal of American Ceramic Society, 2006, 89 (5): 1534-1539.（IF:2.841）